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Prostate Cancer Genetics Program

Prostate Cancer Genetics Project

The Prostate Cancer Genetics Project (PCGP) at the University of Michigan Comprehensive Cancer Center is a research project designed to determine if there is a gene(s) involved in the development of prostate cancer, particularly the type that may be inherited (run in families).

Current Participants

We would also like to ask you about your health and any changes in your family's health, such as new cancers that may have occurred, since the last time we contacted you. Instructions for completing the questionnaire can be found on the form itself at the link below. Please take special note of the three separate categories:

If you are unable to complete the questionnaire or prefer to receive a printed copy with a self-addressed postage-paid envelope, please contact the study office.

Prostate Cancer Genetics Project
1500 E. Medical Center Driver
7436 Cancer Center
Ann Arbor, MI 48109
Phone: 800-723-9170
Fax: 734-647-4338

Since 1995, the University of Michigan Prostate Cancer Genetics Project (PCGP) has been searching for the genetic basis of inherited prostate cancer. We are part of an international consortium of research institutions studying this problem.

Our laboratory researchers process and examine DNA obtained from the blood samples donated by participants. The DNA is obtained from white cells in the blood samples collected from men with prostate cancer and their family members. Human DNA contains approximately 25,000 genes that direct the many functions of the human body.

We suspect that one or more of these genes may contain a variant that contributes to the development of prostate cancer. We have been tracking patterns in DNA sequences suspected to be involved in prostate cancer. By comparing samples from families with multiple cases of prostate cancer, we are closing in on regions of the genome that may contain a prostate cancer susceptibility gene and coming closer to understanding how and why prostate cancer runs in families.

Why is the Prostate Cancer Genetics Program important?

  • Data have shown that prostate cancer may cluster in some families.
  • Men with a family history of prostate cancer are at an increased risk for developing the disease.
  • Prostate cancer risk increases as the total number of affected family members increases.
  • The only way to conquer prostate cancer is through an increased understanding of the disease.
  • Scientific research is the key to learning more about how to detect and treat prostate cancer.

Who can take part in the Prostate Cancer Genetics Program?

  • Males 18 years or older who have had:
    • prostate cancer at a young age (age 55 or younger) or
    • two or more family members diagnosed with prostate cancer, may qualify to participate in the PCGP
  • Any African-American man with prostate cancer may be eligible.

If you know someone who meets these requirements, please pass along this information.

If you decide to enroll, your participation is completely voluntary and confidential. Taking part in this study will not affect your medical care or treatment.

What will happen to me if I participate in the Prostate Cancer Genetics Program study?

If it is found that you are eligible for the study following a brief phone interview, you will be asked to:

  • Complete a short survey over the phone
  • Fill out a family history form about prostate and other forms of cancer
  • Sign a consent to release medical record information relating to your cancer diagnosis, and treatment
  • Provide a small blood sample

You do not have to travel to Ann Arbor, MI or pay any expenses associated with this research as a participant. The forms and blood kit will be posted to you to complete at your convenience.

All information is collected and stored in a secure and confidential manner.

Contact the Prostate Cancer Genetics Project

    Prostate Cancer Genetics Project
    1500 E. Medical Center Drive
    7436 Cancer Center
    Ann Arbor, MI 48109

    Phone: 800-723-9170
    Fax: 734-647-4338

Resources to Print (pdf files):

Family History Form

updated 05.2016

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