A new study provides direct evidence for the role of the Notch pathway in breast cancer stem cell activity as demonstrated by a Notch reporter system. Notch signaling regulates embryonic and tissue-specific stem cells, which are altered in a number of cancers, including breast cancer.
A set of guidelines developed to help standardized lung cancer screening would have generated considerably fewer false-positives than the National Lung Screening Trial produced, according to a new retrospective study.
The Centers for Medicare and Medicaid Services have finalized coverage guidelines for lung cancer screening with CT scans for people at high-risk of developing lung cancer. Coverage goes into effect immediately.
A new study from researchers at the University of Michigan Comprehensive Cancer Center sheds light on the KRAS pathway with a potential target that might have more success at stopping lung cancer growth.
Researchers at the University of Michigan Comprehensive Cancer Center have received a grant from the Lustgarten Foundation worth $1.5 million for a project focused on using a pancreatic cancer patient's blood sample to determine the best treatments.
Researchers at the University of Michigan Comprehensive Cancer Center analyzed the global landscape of a portion of the genome that has not been previously well-explored. This analysis opens the door to discovery of thousands of potential new cancer biomarkers.
New research helps explain why pancreatic cancer is so lethal, with fewer than a third of patients surviving even early stage disease.
A new study characterizes the genetic underpinnings of a rare type of breast tumor called phyllodes tumors, offering the first comprehensive analysis of the molecular alterations at work in these tumors.
One of the mysteries in cancer biology is how one protein, TGF-beta, can both stop cancer from forming and encourage its aggressive growth. Now, researchers at the University of Michigan Comprehensive Cancer Center have uncovered a key gene that may explain this paradox and provide a potential target for treatment.
By analyzing the DNA and RNA of lung cancers, researchers at the University of Michigan Comprehensive Cancer Center found that patients whose tumors contained a large number of gene fusions had worse outcomes than patients with fewer gene fusions.