University of Michigan researchers have found that a particular protein -- TRIP13 -- encourages those cancer cells to repair themselves. And they have identified an existing chemical that blocks this mechanism for cell repair. And they have identified an existing chemical that blocks this mechanism for cell repair. "This is a very significant advance, because identifying the function of the protein that fuels the repair of cancer cells and having an existing chemical that blocks the process, could speed the process of moving to clinical trials," said principal investigator Nisha D'Silva, U-M professor of dentistry and associate professor of pathology.
The number of younger men diagnosed with prostate cancer has increased nearly 6-fold in the last 20 years, and the disease is more likely to be aggressive in these younger men, according to a new analysis.
African-Americans with colon cancer are half as likely as Caucasian patients to have a type of colon cancer that is linked to better outcomes. The finding may provide insight into why African-Americans are more likely to die of colon cancer than Caucasians with the same stage of disease.
In the last 30 years, since mammography was introduced, late-stage breast cancer incidence has decreased by 37 percent, a new study from the University of Michigan Comprehensive Cancer Center finds.
Among men treated for prostate cancer, those who received radiation therapy were more likely to develop bladder or rectal cancer, according to a new study.
New research represents a significant change in the understanding of how pancreatic cancer grows – and how it might be defeated.
About 70 percent of women who have both breasts removed following a breast cancer diagnosis do so despite a very low risk of facing cancer in the healthy breast, a new study finds.
A subset of immune cells directly target colon cancers, rather than the immune system, giving the cells the aggressive properties of cancer stem cells. The researchers are now looking at potential drugs that might target this process directly.
Researchers surveyed woman in Detroit and Los Angeles who had been diagnosed with early stage breast cancer. They narrowed their sample to the 746 women who reported working at the time they were diagnosed. Participants were surveyed about nine months after diagnosis, and then given a follow-up survey about four years later.
Prostate cancer becomes deadly when anti-hormone treatments stop working. Now a new study suggests a way to block the hormones at their entrance. Researchers from the University of Michigan Comprehensive Cancer Center have found that a protein called BET bromodomain protein 4 binds to the hormone androgen receptor downstream of where current therapies work – targeting androgen receptor signaling.