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Basic Science Division

Associate Director: Stephen Weiss, M.D.

Cancer Hematopoiesis and Immunology

Pavan Reddy, M.D., co-leader     Weiping Zou, M.D., Ph.D., co-leader

Specific Aims:

  • Aim 1: To elucidate cellular and molecular mechanisms that govern interactions between immune cells, factors, and signaling in the cancer setting
  • Aim 2: To dissect cellular and molecular regulation of blood and marrow transplant immunology
  • Aim 3: To evaluate the utility and impact of laboratory discoveries for new approaches in cancer and transplantation patients

Cancer Genetics Program

David Beer, Ph.D., co-leader     Kathy Cho, M.D., co-leader

Specific Aims:

  • Aim 1: To make impactful discoveries that provide new insights into the genetic and epigenetic mechanisms of cancer development and progression.
  • Aim 2: To translate new knowledge into effective strategies for prevention, early diagnosis, and treatment of cancer.
  • Aim 3: To develop novel animal model systems for testing effects of critical genetic alterations found in human cancers.

Cancer Biology

    Anj Dlugosz, M.D., co-leader     Marina Pasca Di Magliano, Ph.D., co-leader

    Specific Aims TBD

Developmental Therapeutics

Shaomeng Wang, Ph.D., co-leader     Judy Leopold, Ph.D., co-leader

Specific Aims:

  • Aim 1: Validate novel cancer targets that are amenable to pharmacological intervention.
  • Aim 2: Evaluate promising therapeutic agents and biomarkers in clinically relevant preclinical model systems.
  • Aim 3: Advance preclinical proof of concept studies into biomarker-enabled clinical trials.

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