Transgenic Animal Models
Established Transgenic Technology
Long established as a significant shared resource for cancer investigators, research efforts at the University of Michigan Comprehensive Cancer Center are supported by the team of transgenic animal model specialists who are able to provide complex technology solutions. Working in collaboration with the Bacterial Artificial Chromosome Recombineering Core, we provide effective tools for successful research. In addition, our collaborative approach allows researchers to use transgenic shared resource laboratory space and work side-by-side with staff members.
Efficient and Effective Operations
The Transgenic Animal Models team works with investigators to generate genetically modified animal models to increase our understanding of human diseases. With skilled expertise and unique service, we provide:
- Guaranteed production of transgenic mice and rats with plasmid or BAC transgenes
- Guaranteed production of knockout mice and rats with CRISPR/Cas9 reagents
- CRISPR/Cas9 project pipeline for SNPs, knockins, floxed alleles and knockouts
- Gene targeting in C57BL/6 and 129/Sv ES cell lines
- Production of mouse models from gene-targeted KOMP ES cell clones
- Training in transgenic technology
- Open access to core laboratory equipment and ES cell reagents
Laboratory Protocols and Sample Submission Instructions
For the most efficient and effective processing of transgenic animal models for research, our team at the Transgenic Animal Models Shared Resource provides helpful information such as laboratory protocols, sample submission instructions, forms and commonly asked questions.
Contact Transgenic Animal Models Shared Resource
For more information about transgenic animal models through Shared Resources at the University of Michigan Comprehensive Cancer Center, contact our team leadership or visit our Transgenic Animal Model Core Biomedical Research Core Facilities website.
Transgenic Animal Model Shared Resource
Director: Thom Saunders, Ph.D.
Location: 2570 MSRB II