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Transgenic Animal Models

Director: Thom Saunders, Ph.D.

Location: 2570 MSRB II
Phone: 647-2910
Website: med.umich.edu/tamc

This Core works with investigators to generate genetically modified animal models to increase our understanding of human diseases.

Unique characteristics set the Transgenic Core apart from its peers include:

1. Guaranteed production of transgenic mice and rats with plasmid or BAC transgenes

2. Guaranteed production of knockout mice and rats with CRISPR/Cas9 reagents

3. CRISPR/Cas9 project pipeline for SNPs, knockins, floxed alleles, and knockouts

4. Gene targeting in C57BL/6 and 129/Sv ES cell lines

5. Production of mouse models from gene-targeted KOMP ES cell clones

6. Training in transgenic technology

7. Open access to Core laboratory equipment and ES cell reagents