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Drs. Hussain and Chinnaiyan Receive Grants from the Movember Prostate Cancer Foundation Challenge

Movember is a global men’s health organization that raises money for research into prostate cancer, testicular cancer and other men’s health issues. Each November, the group encourages men to grow moustaches to show their support for research into cancers that affect men. While encouraging a spirit of fun and positivity, Movember enables world-wide research into some of the toughest and most important medical questions in men’s health.

Earlier this fall, the group, in collaboration with the Prostate Cancer Foundation Challenge, awarded two grants to University of Michigan Comprehensive Cancer Center researchers, Maha Hussain, M.D., and Arul Chinnaiyan, M.D., Ph.D.

Hussain, along with U-M co-investigator Felix Feng, M.D., received $1 million. Her project will seek to determine if men with hormone-sensitive, metastatic prostate cancer who are given a novel combination of drugs can delay the onset of resistance to androgen deprivation therapy, and thus delay progression to end-stage disease.

Chinnaiyan, with co-investigators Feng, Shaomeng Wang, Ph.D., and Irfan Asangani, Ph.D., will use a $1.5 million award to develop a new method of targeting the androgen receptor signaling pathway. They will develop an entirely new drug that prevents the genes the androgen receptor protein regulates from being turned “on" and making their protein products, which act to drive cancer progression. The researchers believe that such a "downstream" approach may prove more durable and make it less likely for men to develop resistance to their novel drug because most mechanisms of resistance are “upstream” of the drug target.

Learn more about Dr. Hussain and metastatic prostate cancer:

Learn more about Dr. Chinnaiyan's research:

Questions? Contact Cancer AnswerLine™ at 800-865-1125.

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