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New, Non-Invasive Prostate Cancer Test Now in Use at Michigan Medicine

Media contact: Nicole Fawcett, 734-764-2220 |  Patients may contact Cancer AnswerLine™, 800-865-1125

Every year in America, more than a million men will undergo a prostate biopsy; only one-fifth of those biopsies will result in a cancer diagnosis. The reason is that the traditional prostate cancer screening test — a blood test to measure prostate specific antigen (PSA) — does not give doctors a complete picture.

A more accurate non-invasive test would drastically reduce the number of prescribed biopsies — and the stress, discomfort and expense that go along with them.

Now, the University of Michigan has begun offering a new urine test called Mi-Prostate Score to improve on PSA screening for prostate cancer. The test, developed in a U-M research lab, incorporates three specific markers that could indicate cancer; studies have shown that the combination is far more accurate than PSA alone.

"Many more men have elevated PSA than actually have cancer but it can be difficult to determine this without biopsy," says Scott Tomlins, M.D., Ph.D., assistant professor of pathology and of urology at the University of Michigan. "We need new tools to help patients and doctors make better decisions about what to do if serum PSA is elevated. Mi-Prostate Score helps with this."

Researchers validated the new test on nearly 2,000 urine samples. Mi-Prostate Score, or MiPS, was significantly more accurate than PSA alone for predicting cancer as well as predicting aggressive prostate cancer that is likely to grow and spread quickly.

Mi-Prostate Score developed from a 2005 discovery in the lab of Arul Chinnaiyan, M.D., Ph.D., of a genetic anomaly that occurs in about half of all prostate cancers, an instance of two genes changing places and fusing together.

This gene fusion, T2:ERG, is believed to cause prostate cancer. Studies in prostate tissues show that the gene fusion almost always indicates cancer.

The new urine test looks for the T2:ERG fusion as well as another marker, PCA3. This is combined with serum PSA measure to produce a risk assessment for prostate cancer.

The test also predicts risk for having an aggressive tumor, helping doctors and patients make decisions about whether to wait and monitor test levels or pursue immediate biopsy.

"This combination test is not designed to say definitively at diagnosis whether a man has aggressive prostate cancer, but it can provide a more accurate estimate of the likelihood of having cancer and the likelihood of that cancer being aggressive," Tomlins says.

The test is available to anyone but requires a request from a doctor. For further information, call the University of Michigan's MLabs at 800-862-7284.

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